Hot Selling Good Quality 99% Fast Delivery Linezolid CAS 165800-03-3

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: Frazer- Linezolid
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Store in a Well-Closed Container Away From Moistur
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• MOQ: 500g
• CAS No: 165800-03-3
• Grade: Pharm Grade
• Mf: C16h20fn3o4
• MW: 337.35
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 600kg Per Month

Product Description

Hot Selling Good Quality 99% Fast Delivery Linezolid CAS 165800-03-3

 

 

Product Details

 

What is Linezolid?

Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. A member of the oxazolidinone class of drugs, linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).

The main indications of linezolid are infections of the skin and soft tissues and pneumonia (particularly hospital-acquired pneumonia), although off-label use for a variety of other infections is becoming popular.

 Function of Linezolid?

The oxazolidinones are protein synthesis inhibitors: they stop the growth and reproduction of bacteria by disrupting translation of messenger RNA (mRNA) into proteins in the ribosome. Although its mechanism of action is not fully understood, linezolid appears to work on the first step of protein synthesis, initiation, unlike most other protein synthesis inhibitors, which inhibit elongation.[89][95]

It does so by preventing the formation of the initiation complex, composed of the 30S and 50S subunits of the ribosome, tRNA, and mRNA. Linezolid binds to the 23S portion of the 50S subunit (the center of peptidyl transferase activity),[96] close to the binding sites of chloramphenicol, lincomycin, and other antibiotics. Due to this unique mechanism of action, cross-resistance between linezolid and other protein synthesis inhibitors is highly infrequent or nonexistent

Application

Linezolid is an inhibitor of bacterial protein synthesis. Linezolid showed good antibacterial activity against methicillin-sensitive or drug-resistant staphylococcus, vancomycin-sensitive or drug-resistant enterococcus, penicillin-sensitive or drug-resistant Streptococcus pneumoniae, and also against anaerobic bacteria. Unlike other drugs, linezolid does not affect peptidyl transferase activity. Linezolid has a unique site and mode of action, so it is not easy to cross resistance with other antibacterial drugs that inhibit protein synthesis in positive bacteria with intrinsic or acquired resistance, and it is not easy to induce bacterial resistance in vitro.

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