Dihydroberberine 483-15-8

• Customization: Available
• Certification: ISO
• Assay Method: HPLC
• Model NO.: 2024333
• Transport Package: Drum
• Specification: box
• Trademark: gm5
• Origin: Jiangsu, Shaanxi, Beijing
• HS Code: 20240
• Production Capacity: 800ton/Year

Product Description

Dihydroberberine inhibits the human ether-associated gene (hERG) channel, significantly reducing the expression of heat shock protein 90(Hsp90) and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherogenic, hypolipidemic and anti-tumor activities.


 

DHB exerts its uric acid-lowering effect by inhibiting the activation of XOD, URAT1, GLUT9, and NLRP3 inflammatory vesicles in the kidneys, and is renoprotective in addition to being antihyperuricemic.
The treatment of DHB had a protective effect on renal function.
These results suggest that DHB ameliorates renal injury and has a nephroprotective effect in HUA mice.
DHB showed XOD enzyme inhibition in a concentration-dependent manner.DHB significantly inhibited XOD activity (Figure 4D). This result suggests that DHB has an inhibitory effect on XOD.
Treatment with DHB was effective in ameliorating PO/HX-induced renal inflammation.
DHB showed the ability to inhibit XOD activity both in vitro and in vivo.
And the treatment of DHB also showed significant inhibition of renal URAT1 and GLUT9 levels.
Thus, DHB was able to reduce urate formation by inhibiting hepatic XOD while down-regulating renal URAT1 and GLUT9 to enhance urate excretion, suggesting a dual anti-hyperuricemic effect.
In addition, the mechanism by which DHB exerts its renoprotective effects was found to be through the inhibition of NLRP3 inflammasome activation to attenuate renal inflammation and dysfunction.

 

 

Application

Health Care Products, Food, Daily Necessities, Cosmetics, Functional Drink
 

Packaging & Shipping

 

Package	1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements.
Transit	Fedex, TNT,DHL,EMS,and so on.
Shipping port	Shanghai/Tianjin/Dalian/Beijing/Xi'an
Lead Time	1-2 working days upon received the payment
For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea.