Pharmaceutical Material Antifungal Antibiotic Nystatin Powder CAS 1400-61-9

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: Frazer-Nystatin
• Suitable for: Elderly, Children, Adult
• State: Yellow Powder
• Purity: >99%
• CAS No.: 1400-61-9
• Appearance: Yellow Powder
• Shelf Life: 2 Years
• Storage: Store in a Well-Closed Container Away From Moistur
• Form: Powder
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• Einecs: 615-996-8
• M.F.: C47h75no17
• Application: Antibiotics
• Transport Package: Foil Bag
• Specification: 1kg Per Foil Bag, 10 Bags Per Carton, 25 Kg Per Dr
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 1000kg/Month

Product Description

Pharmaceutical Material Antifungal Antibiotic Nystatin Powder CAS 1400-61-9
 

Nystatin is a polyene antifungal drug to which many molds and yeast infections are sensitive, including Candida.

Cutaneous, vaginal, mucosal and esophageal Candida infections usually respond well to treatment with nystatin.

Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage and death of the fungus.

Function:

1). Nystatin is often used as prophylaxis in patients who are at risk for fungal infections.

2). It is prescribed in units, with doses varying from 100,000 (for oral infections) to 1 million (for intestinal ones). As it is not absorbed from the gut, it is safe for oral use and does not have problems of drug interactions.

3). It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 µg/mL.

4). In certain cases, nystatin has been used to prevent the spread of mold on objects such as works of art. For example, it was applied to wood panel paintings damaged as a result of the Arno River Flood of 1966 in Florence, Italy.

5). Nystatin is also used as a tool by scientists performing "perforated" patch-clamp electrophysiologic recordings of cells. When loaded in the recording pipette, it allows for measurement of electrical currents without washing out the intracellular contents, because it forms pores in the cell membrane that are permeable to only monovalent ions.

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Specification of Analysis

Test items		Standard	Result
Description		Light yellow powder	Conforms
Identification	IR	IR spectrum of sample is the same as working standard	Conforms
	HPLC	HPLC RT of the sample is the same as the working standard	Conforms
Melting point		165.0°C~169.0°C	Conforms
Optical rotation		-23°~-29°	-27.4°
Loss on drying		NMT 1.0 %	0.17%
Residue on ignition		NMT 0.1 %	0.03%
Heavy metals		NMT 20ppm	Conforms
Related substances
Impurity A		NMT 0.1 %	Not detected
Impurity B		NMT 0.1 %	Not detected
Impurity C		NMT 0.1 %	0.02%
Single impurity		NMT 0.2 %	0.17%
Total impurity		NMT 1.0 %	0.60%
Assay		NLT 99.0%	99.0%