Factory Supply 99% High Purity Tofacitinib Citrate CAS 540737-29-9

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Tofacitinib
• CAS No.: 540737-29-9
• Mf: C22h28n6o8
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Store in a Well-Closed Container Away From Moistur
• Chemical Name: Tofacitinib Citrate
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 98%
• MOQ: 1kg
• MW: 461.46
• Transport Package: Bag
• Specification: Cholecalciferol
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 200kg Per Month

Product Description

Factory Supply 99% High Purity Tofacitinib Citrate CAS 540737-29-9

 

Basic Information:  

Items	Standards	Results
Appearance	White or off-white solid powder	White solid powder
Identification	By IR	Complies
Loss on Drying	≤ 0.50%	0.32%
Heavy Metal	≤ 10ppm	Complies
Residue on Ignition	≤ 0.20%	0.05%
Enantiomer	(SS) ≤0.1%	ND
Citrate	36.2% ~ 40.0% (on dried basis)	37.3%
Residual Solvents	: ≤3000ppm	ND
	Ethanol: ≤5000ppm	260ppm
	: ≤5000ppm	ND
	: ≤5000ppm	ND
	n-Butyl alcohol: ≤5000ppm	ND
	: ≤600ppm	ND
Related Substances	(RS+SR): ≤0.10%	ND
	Any single impurity: ≤0.10%	0.07%
	Total Impurities: ≤0.30%	0.21%
Assay (HPLC basis on drying)	99.0%~101.0%	99.85%
Particle Size	D90: ≤50µm	27.61µm
Reference Standard	In-house Standard
Conclusion	The product complied with In-house standards.
Storage	Preserve in tight,light-resistant containers in a cool place

Tofacitinib citrate is an oral drug used for treating rheumatoid arthritis. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune response that causes the pain, tenderness and swelling of inflammation. JAKs are found in many cells, especially stem cells in bones and joints. Inhibition of JAKs by tofacitinib prevents inflammation and tissue destruction that is associated with the inflammation of rheumatoid arthritis.

Function:

(1).Tofacitinib citrate is an oral, small molecule drug used to treat adults with moderate-to-severe, active rheumatoid arthritis who have not responded well to being treated with methotrexate. Methotrexate is a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis (RA).
(2).Tofacitinib acts to block the body's production of enzymes called Janus kinases (JAKs). JAKs play a role in joint inflammation in RA, which can cause pain, swelling and stiffness. If left untreated, RA inflammation could lead to joint erosions, and organ and tissue damage. It may be used alone or in combination with methotrexate or other DMARDs.