Factory Supply 98% Ivabradine Hydrochloride Powder CAS 148849-67-6 with Best Quality

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Ivabradine Hydrochloride
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Keep in Cool and Dry Place
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• Shipping Area: Worldwide/All Countries
• CAS: 148849-67-6
• Mf: C27h37cln2o5
• MW: 505.046
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 200kg Per Month

Product Description

Factory Supply 98% Ivabradine Hydrochloride Powder CAS 148849-67-6 with Best Quality

 

Specification of Analysis

ITEM	SPECIFICATION	RESULT
Appearance	White to off-white powder	White powder
Identification	Correspond to reference chromatograph	Conform
Purity(HPLC)	≥99.0%	99.72%
Max single impurity	≤ 0.1%	0.09%
Total impurities	≤ 0.5%	0.28%
Isomer	≤ 0.1%	0.006%
Assay(HPLC)	≥98.0%	99.6%
Loss on drying	≤ 1.0%	0.77%
Moisture content	≤ 1.0%	0.33%
Residue On Ignition	≤0.2%	0.05%
Heavy metal	≤ 20ppm	Conform
Specific optical rotation	+6.5°-- +8.5°	+7.34°
Result	Qualified
Storage	Sealed,avoid light,at room temperature.

Description:

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane.

As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) - 80% (10 mM).

Usage:

Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal

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