Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Items | Standards | Results | |
Appearance | Off-white to white solid powder | Complies | |
Identification | By IR | Complies | |
By HPLC | Complies | ||
Solubility | Freely soluble in DMSO, slightly soluble in ethanol and water | Complies | |
Melting Point | 228ºC~230ºC | 228.8ºC~229.5ºC | |
Loss on Drying | ≤ 0.50% | 0.23% | |
Heavy Metal | ≤ 10ppm | Complies | |
Residue on Ignition | ≤ 0.10% | 0.06% | |
Related Substances | Any single impurity: ≤0.10% | 0.08% | |
Total Impurities: ≤1.00% | 0.22% | ||
Assay (HPLC basis on drying) |
98.0%~102.0% | 99.79% | |
Reference Standard | In-house Standard | ||
Conclusion | The product complied to In-house standard. | ||
Storage | Preserve in tight,light-resistant containers in a cool place |
Baloxavir marboxil is a white crystalline powder. Baloxavir marboxil is a new hat-dependent endonuclease inhibitor that kills influenza viruses within 24 hours, but some symptoms can last longer. Baloxavir marboxil inhibits virus replication by different mechanisms from existing anti-flu drugs.
Baloxavir marboxil is used to treat influenza A and influenza B infections. The drug was initially approved for marketing in Japan in February 2018, and was approved by the FDA on October 24, 2018 for the treatment of acute uncomplicated influenza patients 12 years of age and older who have symptoms for no more than 48 hours. Baloxavir marboxil is a cap endonuclease inhibitor, which has a unique mechanism of action compared with the class of neuraminidase inhibitor drugs currently used to treat influenza infections.
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