99% Safe Purity Pharmaceutical Raw Material Powder 53123-88-9 Rapamycin

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Rapamycin
• Appearance: White Powder
• CAS No: 53123-88-9
• Shelf Life: 2 Years
• Test Method: HPLC
• Storage: Store Cool Dry Place
• Resource: Natural
• Quality Requirement: Strictly Quality Control
• Molecular Formula: C51h79no13
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 2000kg/Month

Product Description

99% Safe Purity Pharmaceutical Raw Material Powder 53123-88-9 Rapamycin

Item	Specifications
Assay ,%	98.0% to 102.0% calculated trans- and cis-Stereoisomer of Sirolimus on the dried basis
Appearance	White crystalline powder
Loss On Dry	Not More Than 0.50%
Heavy Metals	Not More Than 0.002%
Individual Impurity	Not More Than 1.0%
Total Impurities	Not More Than 2.0%
Cis-Stereoisomer of Sirolimus	Not More Than 5.0%
Ethanol	≤5000PPM
Acetonemia	≤5000PPM

Rapamycin is produced by the soil bacterium Streptomyces hygroscopicus. The drug's name comes from Rapa Nui, the indigenous name of Easter Island, where the compound was originally discovered in soil samples in the 1970s.

Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.

Application:

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.

Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

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