99% Medicine Grade Terbinafine HCl 78628-80-5

Product Details
Customization: Available
Powder: Yes
Customized: Customized
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  • 99% Medicine Grade Terbinafine HCl 78628-80-5
  • 99% Medicine Grade Terbinafine HCl 78628-80-5
  • 99% Medicine Grade Terbinafine HCl 78628-80-5
  • 99% Medicine Grade Terbinafine HCl 78628-80-5
  • 99% Medicine Grade Terbinafine HCl 78628-80-5
  • 99% Medicine Grade Terbinafine HCl 78628-80-5
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Basic Info.

Model NO.
Frazer-Terbinafine HCl
Certification
GMP, HSE, ISO 9001, USP, BP
Suitable for
Elderly, Children, Adult
State
White Powder
Purity
>99%
Appearance
White Powder
CAS No
78628-80-5
Shelf Life
2 Years
Test Method
HPLC
MOQ
1kg
Storage
Store Cool Dry Place
Resource
Natural
Quality Requirement
Strictly Quality Control
Market
Worldwide
Service
Welcome to Visit Us
MW
327.9
Mf
C21h25n·HCl
Transport Package
Foil Bag
Specification
99%
Trademark
Xi′an Frazer Biotech Co., Ltd.
Origin
China
Production Capacity
2000kg/Month

Product Description

99% Medicine Grade Terbinafine HCl 78628-80-599% Medicine Grade Terbinafine HCl 78628-80-5
99% Medicine Grade Terbinafine HCl 78628-80-5

 

Specification of Analysis
Items Specifications Results
Appearance White or almost white powder White powder
Solubility Practically insoluble in water and in aceton, soluble in ethanol and in m'ethanol Complies
A: IR The infrared absorption spectrum exhibits maximum only at the same wavelengths as that of the standard sample Complies
B:       It gives reaction of chlorides Complies
Impurity A NMT 0.1% 0.00%
Impurity B NMT 0.1% 0.01%
Impurity C NMT 0.1% 0.02%
Impurity D NMT 0.1% 0.02%
Any other impurity NMT0.1% 0.05%
Total of impurity NMT 0.3% 0.15%
Loss on drying NMT0.5% 0.15%
Sulphated ash NMT0.1% 0.02%
Assay 99%~101% (dried substance ) 99.85%

Product Description:
Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate in hair, skin, nails, and fatty tissue.
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in m'ethanol and di'ch'loromethane, soluble in ethanol, and slightly soluble in water.
Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesize.

Application Aera:
1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250-mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. 
4. Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.

 

99% Medicine Grade Terbinafine HCl 78628-80-5

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