| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Items |
Standards |
Results |
|
Physical Analysis |
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|
Description |
White Powder | Complies |
|
Assay |
99% | Complies |
|
Mesh Size |
100 % pass 80 mesh | Complies |
|
Ash |
≤ 5.0% | 2.85% |
|
Loss on Drying |
≤ 5.0% | 2.65% |
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Chemical Analysis |
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|
Heavy Metal |
≤ 10.0 mg/kg |
Complies |
|
Pb |
≤ 2.0 mg/kg |
Complies |
|
As |
≤ 1.0 mg/kg | Complies |
|
Hg |
≤ 0.1mg/kg | Complies |
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Microbiological Analysis |
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|
Residue of Pesticide |
Negative | Negative |
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Total Plate Count |
≤ 1000cfu/g | Complies |
|
Yeast&Mold |
≤ 100cfu/g | Complies |
|
E.coil |
Negative |
Negative |
|
Salmonella |
Negative |
Negative |
Description:
Telmisartan, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid (Micardis), does not appear to bear any structuralrelationship to this class, but there is actually a great dealof overlap in the chemical architecture with other agents.
The first, and most significant, difference is the replacement of the acidic tetrazole system with a simple carboxylic acid. This acid, like the tetrazole, plays a role in receptor binding.
The second difference is the lack of a carboxylic acid near the imidazolenitrogen that also contributes to receptor binding.As with irbesartan, however, there is not a need for this groupto be acidic but, rather, to be one that participates in receptorbinding. The second ring, much like a purine basein deoxyribonucleic acid (DNA), can hydrogen bond with theangiotensin II receptor.
Usage:
Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus.
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