| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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ITEMS |
SPECIFICATIONS |
RESULTS |
|
Appearance |
White crystalline powder, soluble in water, very slightly soluble in e and in alcohol
|
Conforms |
|
Identification |
IR
|
Conforms |
|
Appearance of solution
|
Solution is clear and colorless
|
Conforms |
|
Acidity |
To 10ml of solution S1 add 0.1ml of phenolphthalein solution R1,the solution is colourless,not more than 0.7 ml of 0.01Me is required to change the colour of the indicator to pink
|
Conforms |
|
PH |
5.0~7.0 |
6.3 |
|
Loss on drying |
≤05% |
0.08% |
|
Residue on Ignition |
≤0.3% |
0.3% |
|
Transmittance |
≥97% |
97.2% |
|
Water-insoluble matter
|
≤0.5% |
0.21% |
|
Limit of 1,1-cyclobutane- dicarboxylic acid |
≤0.5% |
N.D |
|
Chromatographic purity: Individual impurity: All impurities: |
≤0.25% ≤0.5% |
0.077% 0.19%
|
|
Platinum content |
52.0% - 53.0% |
52.33% |
|
Chlorides |
≤100ppm |
Conforms |
|
Ammonium |
≤100ppm |
Conforms |
|
Silver |
≤10ppm |
Conforms |
|
Soluble barium |
≤10ppm |
Conforms |
|
Assay |
98.0%-102.0% |
99.2% |
|
Conclusiion |
This product complied with the standard of USP |
|
Carboplatin is a second-generation platinum antitumor drug with similar anticancer activity as cisplatin, but nephrotoxicity, ototoxicity, neurotoxicity, especially gastrointestinal reactions, are significantly lower than cisplatin, and the antitumor spectrum is inferior to cisplatin. wide. Its mechanism of action is mainly to cause DNA chain and intra-chain cross-linking, interfere with DNA molecules, inhibit cell DNA synthesis, mainly acts on the N-7 and O-6 atoms of guanine of DNA, and produces cytotoxic effects.
1. Carboplatin mainly used for small cell lung cancer, ovarian cancer, testicular cancer, head and neck squamous cell carcinomas, etc
2. Carboplatin can be used for non-small cell lung cancer, bladder cancer, cervical cancer, pleural mesothelioma, melanoma and endometrial cancer
3. Carboplatin can also be used for digestive cancer, liver cancer and radiation treatment efficiency
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