| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Description:
Domperidone is a peripheral, specific blocker of dopamine receptors. It is administered orally, rectally, or intravenously. Domperidone is given in order to relieve nausea and vomiting; to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin. It is also used in the scientific study of the way dopamine (an important neurotransmitter) acts in the body.
Application:
It can be used in patients with Parkinson's disease because, unlike metoclopramide, domperidone does not cross the blood-brain barrier.
Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated "for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis." The drug may also be used "to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents".
COA:
| Items | Requirements | Results |
| Appearance | White to off white powder | White powder |
| Solubility |
Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethanol(96%) and in methanol |
Confirms |
| Identification | A. M.P. 244~248ºC | 244.5~245.5ºC |
| B. IR should comply | Confirms | |
| C. TLC should comply | Confirms | |
| D. It gives the reaction of non-nitrogen substituted barbiturates. | Confirms | |
| Clarity of solution |
The solution is clear and not more intensely colored than reference solution Y6 |
Confirms |
| Related substance | Total impurities≤0.5% | ≤0.29% |
| Individual impurity≤0.25% | ≤0.18% | |
| Loss on drying | ≤0.5% | 0.07% |
| Sulphated ash | ≤0.1% | ≤0.05% |
| Heavy metal | ≤20ppm | <20ppm |
| Assay | 99.0%~101.0% | 99.49% |
| Conclusion: This product conforms to the EP7.0 detection. | ||
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