| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Items |
Specification |
Result |
|
Assay |
≥98% |
99% |
|
Apperance |
White crystalline powder |
Complies |
|
PH |
2.0~4.0 |
2.5 |
|
Heavy metals |
≤10ppm |
Complies |
|
Total impurities |
≤0.5% |
0.06% |
|
Single impurity |
≤0.1% |
0.04% |
|
Unspecific impurity |
≤0.1% |
0.06% |
|
Water |
5.0%-7.0% |
5.1% |
Zoledronic acid, one of the most potent nitrogen-containing bisphosphonates, induces anti-proliferative and apoptotic effects on multiple myeloma cell lines in vitro by activating protein kinase C. Zoledronic acid also inhibits proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM. In cultures of freshly isolated rabbit and human osteoclasts zoledronic acid (10-100 μM) induced morphological features similar to apoptosis and Osteoclastogenesis was inhibited with an IC50 of 15 nM.
Function
This medication is used to treat high blood calcium levels (hypercalcemia) that may occur with cancer. Zoledronic acid is also used with cancer chemotherapy to treat bone problems that may occur with multiple myeloma and other types of cancer (such as breast, lung) that have spread to the bones. Zoledronic acid belongs to a class of drugs known as bisphosphonates. It lowers high blood calcium levels by reducing the amount of calcium released from your bones into your blood. It also works by slowing the breakdown of your bones by cancer to prevent bone fractures.
Application
Zoledronic acid also known as zoledronate, is a medication used to treat a number of bone diseases.Thisinclude osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, and Paget's disease of bone. It is given by injection into a vein.
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