China Factory Supply Linagliptin CAS 668270-12-0 Linagliptin Powder

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Keep in Cool and Dry Place
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• MOQ: 1kg
• Shipping Area: Worldwide/All Countries
• CAS: 668270-12-0
• MW: 472.54
• Melting Point: 202ºC
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 200kg Per Month

Product Description

China Factory Supply Linagliptin CAS 668270-12-0 Linagliptin Powder

Specification of Analysis

items	Specifications	Results
Appearance	White or off-white crystalline powder	Conforms
HPLC	The retention time of the major peaking the chromatogram of the sample corresponds to that exhibited by the working standard	Conforms
Loss on drying	No more than 1.0%	0.40%
Residue on Ignition	No more than 0.1%	0.02%
Heavy Metals	No more than 20ppm	<10ppm
Related substances	Total impurities no more than 1.0%	0.50%
	Single impurity no more than 0.5%	Conforms
Residual solvents	Eth yl ac etate No more than 0.1%	Conforms
	Ethanol No more than 0.1%	Conforms
Purity	No less than 99.0%	99.50%

Description

Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for treatment of type II diabetes.

Linagliptin was approved by the U.S. Food and Drug Administration (FDA) on 2 May 2011 for treatment of type II diabetes. 

Application

Linagliptin  is a kind of dipeptide peptidase 4 (DPP - 4) inhibitors used as dietary and exercise in type 2 diabetes in adult auxiliary treatment to improve blood sugar control.

Linagliptin is used with a proper diet and exercise program and possibly with othermedications to control high blood sugar. It is used by people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Functions

1. Incretin (Incretin) has the role of intestinal promoting ins ulin B cells to secrete ins ulin, mainly including glucose-dependent ins ulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). DDP-4 is a serine protease located on the cell surface, which is widely found in plasma and in vivo tissues (such as kidney, liver, small intestine villi, endothelial cells, etc.). Rilalitine is a selective DPP-4 inhibitor that inhibits the activity of the enzyme by reversibly binding to DPP-4, delays GLP-1 degradation, enhances GLP-1 activity, and stimulates glucose-dependent Ins ulin secretion, and reduce circulating levels of glucagon, thereby regulating blood glucose levels in patients with type 2 diabetes.

2. Compared with other DPP-4 inhibitors, the main advantages of liradetine is: with excellent renal safety, and can effectively reduce glycosylated hemoglobin. Lilardine mainly in the form of excretion of fecal excretion, the oral administration, the amount of renal excretion is only 5% of the dose, even if the intravenous administration, and only 30.8% of the excretion by the kidney, so the patient did not need treatment Regularly check the liver, kidney function and dose adjustment, all patients can be a unified fixed dose, easy to prescribe.