Top Quality Pure Pimecrolimus Powder CAS 137071-32-0

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP, SGS
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >98%
• Model NO.: Frazer-Pimecrolimus
• CAS No.: 137071-32-0
• Test Method: HPLC
• MOQ: 1kg
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Cool Dry Place
• Delivery: Express 5-7 Days Arrive
• Sample: Available
• Application: Pharmaceutical Grade
• Transport Package: Foil Bag
• Specification: 1kg Per Foil Bag, 10 Bags Per Carton, 25 Kg Per Dr
• Trademark: Frazer
• Origin: China
• Production Capacity: 1000kg/Month

Product Description

Top Quality Pure Pimecrolimus Powder CAS 137071-32-0

Description 
Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations.

Function
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.Target: OthersPimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function. Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin. Pimecrolimus inhibits not only the transcription and synthesis of cytokines from mast cells, but also the release of preformed mediators serotonin and β-hexosaminidase by the inhibition of Fcε-RI-mediated degranulation and secretion.

Application
Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations.

 COA

Batch No.	FLZ210320	Quantity	50kgs
Mfg. Date	Mar. 20, 2021	Package	As required
Rep. Date	Mar. 24, 2021	Exp. Date	Apr. 19, 2023
Items	Standards		Results
Appearance	White or off-white powder		Complies
Identification	By IR		Complies
	By HPLC		Complies
Specific Optical Rotation	-105.0°~-110.0°		-107.6°
Water Content	≤ 2.00%		0.60%
Heavy Metals	≤ 20ppm		Complies
Residual on Ignition	≤ 0.10%		0.06%
Residual Solvents	Acetonitrile ≤410ppm		ND
	Acetone ≤5000ppm		615ppm
	Methanol ≤3000ppm		ND
	Dichloromethane ≤600ppm		ND
	n-Heptane ≤5000ppm		1271ppm
Related Substances	Impurity A: ≤0.50%		ND
	Impurity D: ≤0.50%		0.24%
	Impurity C: ≤0.15%		ND
	Impurity D: ≤0.50%		0.15%
	Each of Unspecified impurity: ≤0.10%		0.04%
	Total Impurities: ≤1.00%		0.44%
Assay (HPLC basis on drying)	98.0%~102.0%		99.20%
Microbial Limit	Total Aerobic: ≤100cfu/g		<10cfu/g
	Total Yeasts and Molds: ≤100cfu/g		<10cfu/g
	Staphylococcus Aureus: Absent		Absent
	Pseudomonas Aeruginosa: Absent		Absent
PSD	D50: ≤ 40µm		12.65µm
	D90: ≤ 100µm		42.80µm
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight,light-resistant containers in a cool place,at temperature 2ºC~8ºC