Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Pyrimethamine
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Store in a Well-Closed Container Away From Moistur
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• MOQ: 1kg
• CAS No: 58-14-0
• Grade: Pharmaceutical Grade
• Delivery Time: Within 24 Hours After Receiving The Payment
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 200kg Per Month

Product Description

Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal

 

Basic Information

Product Name	Pyrimethamine
CAS No.	58-14-0
Apearance	White Crystalline Powder
Molecular Formula	C12H13ClN4
Molecular Weight	248.71
EINECS No.	200-364-2
Brand Name	Biocar
Melting Point	233-234°C
Boiling Point	393.35°C (rough estimate)
Density	1.2171 (rough estimate)
Storage Condition	0-6°C
Shelf Life	2 Years
Delivery Time	7-10 Days
MOQ	100 Gram

Description
Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony in the mosquito, resulting in a decrease of transmission of the infection within the community .

The mechanism of action of pyrimethamine is related to its inhibition of dihydrofolic reductase necessary for the folic acid synthesis in the parasite. Pyrimethamine acts slowly and is not recommended as monotherapy for acute malaria attacks. Resistance to pyrimethamine developed soon when the drug was used on a large scale as monoprophylaxis . In resistant strains, the enzyme dihydrofolic reductase binds to pyrimethamine several hundred times less than in sensitive strains . This high grade resistance is probably a onestep mutation and cannot be overcome by increasing the dose. However, when combined with long-acting sulphonomides (sulphadoxine), the effect of pyrimethamine is potentiated and the risk of developing resistant strains is far less.

Function
Used for pesticides and reagents for analysis.

Used as strong basic catalyst, ethoxylating agent and as reductant for organic synthesis, pharmaceutical synthesis, etc.

Used in medicine industry, such as phenylbutazone, methyldopa, hydrochloride, aminopterin, pyrimethamine, pifu ampicillin and so on.