Manufacturer Supply High Purity CAS 32222-06-3 Calcitriol

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Calcitriol
• Appearance: White Powder
• CAS No: 32222-06-3
• Shelf Life: 2 Years
• Test Method: HPLC
• MOQ: 1kg
• Storage: Store Cool Dry Place
• Resource: Natural
• Mf: C27h44o3
• Store Temperature: 2-8 Degree
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 2000kg/Month

Product Description

Manufacturer Supply High Purity CAS 32222-06-3 Calcitriol

Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
 

Melting point	119-1210C
Boiling point	474.91°C (rough estimate)
Density	1.0362 (rough estimate)
Refractive index	1.4700 (estimate)
Fp	14 °C
Storage temp.	2-8°C
λmax	265nm(lit.)
Merck	14,1644
BRN	7559394
Stability:	Air and Light Sensitive

Function of Calcitriol
Calcitriol is in a class of medications called vitamin D analogs. It works by helping the body to use more of the calcium found in foods or supplements and regulating the body's production of parathyroid hormone.
Calcitriol is used in patients with kidney disease who can't make enough of the active form of Vitamin D.
Calcitriol is a form of vitamin D3. Vitamin D helps your body absorb calcium from the stomach.
Calcitriol is used to treat hyperparathyroidism. 
Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing absorption of dietary calcium.

COA

Ref. Standard	According to enterprise internal control standard inspection
Results Of Analysis Tests
Test	Analysis Standard	Results
Description	Powder	Powder
Identification	(1)304nm,260nm.	confirmed
Melting Point	192°C~196°C	192°C~196°C
Specific Rotation	+124°~ +129°	+127.1°
(HPLC) Related substances	(1)(Single):≤0.5%	0.31%
	(2)(Total):≤1.0%	0.59%
Loss On Drying	≤0.5%	0.1%
Assay	≥98.5%	99.5%
Sieve analysis	≤30μm	confirmed
Conclusion	This product conforms to enterprise internal control standards