Good Price and Hot Sale Methotrexate Powder CAS 59-05-2 for Antineoplastic

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Yellow Crystalline Powder
• Purity: >99%
• Model NO.: Frazer-Methotrexate
• Appearance: Yellow Crystalline Powder
• Shelf Life: 2 Years
• Storage: Keep in Cool and Dry Place
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• MOQ: 1kg
• Shipping Area: Worldwide/All Countries
• CAS: 59-05-2
• Service: Good Service
• Delivery Method: FedEx/DHL/Special Line
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 200kg Per Month

Product Description

Good Price and Hot Sale Methotrexate Powder CAS 59-05-2 for Antineoplastic

Product Description
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

 

Function

1.It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions.
2.It is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.Types of autoimmune diseases
3.It is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.

Application

Methotrexate is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease (although a recent review has raised the point that it is fairly underused in Crohn's disease), eczema and many forms of vasculitis. Although originally designed as a chemotherapy drug (using high doses), in low doses, methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases.

Because of its effectiveness, low-dose methotrexate is now first-line therapy for the treatment of rheumatoid arthritis. Weekly doses are beneficial for 12 to 52 weeks duration therapy, although discontinuation rates are as high as 16% due to adverse effects. Although methotrexate for autoimmune diseases is taken in lower doses than it is for cancer, side effects such as hair loss, nausea, headaches, and skin pigmentation are still common. Use of low doses of methotrexate together with NSAIDS such as aspirin or paracetamol is relatively safe in people being treated for rheumatoid arthritis, if adequate monitoring is done.

Specification

Test  Item	Analysis  Specification	Result
Description	Orange yellow crystalline powder; Novisible  evidence of contamination by foreign matter	Yellow
Identification A:	IR spectrum exhibits maxima only at the same  wavelengths as that of a similar preparation of  the USP reference standard	Conforms
Identification B:	UV spectrum exhibits maxima and minima only  at the same wavelengths as that of a similar  preparation of the USP reference standard	Conforms
Residue on ignition	Not more than 0.1%	0.08%
Specific Rotation	+19° to +24°	+20.6°
Water content	Not more than 12.0%	10.30%
Assay(calculated on  anhydrous basis)	98.0% to 102.0%	99.40%
Chromatographic Purity	Total  Not more than 2.0%	0.70%
	Individual  Not more than 0.5%	0.20%