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Vancomycin is produced by fermentation of Amycol atopsis orientalis (formerly Nocardi a orientalis). It has been available for approximately 40 years, but its popularity has increased significantly with the emergence of MRSA in the early 1980s. Chemically, vancomycin has a glycosy lated hexapeptide chain that is rich in unusual amino acids, many of which contain aromatic rings cross-linked by aryl ether bonds into a rigid molecular framework.
Vancomycin is used for serious bacterial infections caused by microorganisms sensitive to this drug when penicillins and cephalosporins are ineffective for diseases such as sepsis, endocarditis, pneumonia, pulmonary abscess, osteomyelitis, meningitis, and enterocolitis, or when penicillins and cephalosporins cannot be tolerated by patients. Vancomycin is the drug of choice for infections caused by methicillin-resistant forms of S. aureus, S. epidermidus, and other coagulase-negative staphylococci, as well as for endocarditis, diphtherioid infections, and for patients very sick with colitis caused by C. difficile. A synonym of this drug is vancocin
Vancomycin is an antibiotic used to treat a number of bacterial infections.It is recommended intravenously as a first-line treatment for complicated skin infections,bloodstream infections, endocarditis, bone and joint infections, and meningitis caused bymethicillin-resistants. aureus. Blood levels may be measured to determine the correct dose.Vancomycin is also recommended by mouth as a treatment for severe Clostridium difficilecolitis. When taken by mouth it is very poorly absorbed.