Raw Material Top Quality Valsartan CAS 137862-53-4 with High Quality

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Valsartan
• Appearance: White Powder
• CAS No: 137862-53-4
• Shelf Life: 2 Years
• Test Method: HPLC
• MOQ: 1kg
• Storage: Store Cool Dry Place
• Resource: Natural
• Quality Requirement: Strictly Quality Control
• Mf: C24h29n5o3
• Melting Point: 116-117°c
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 1000kg/Month

Product Description

Raw Material Top Quality Valsartan CAS 137862-53-4 with High Quality

What is Valsartan?

Valsartan (trade name Diovan) is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack.

Function
Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack.
There is contradictory evidence with regard to treating people with heart failure with a combination of an angiotensin receptor blocker like valsartan and an angiotensin-converting enzyme inhibitor, with two major clinical trials (CHARM-additive and ValHeFt) showing a reduction in death, and two others (VALIANT and ONTARGET) showing no benefits, and more adverse effects including heart attacks.
In people with type II diabetes and high blood pressure or albumin in the urine, valsartan is used to slow the worsening and the development end-stage renal disease.

Application 
Valsartan blocks the actions of angiotensin II, which include constricting blood vessels and activating aldosterone, to reduce blood pressure.The drug binds to angiotensin type I receptors (AT1), working as an antagonist. This mechanism of action is different than the ACE inhibitor drugs, which block the conversion of angiotensin I to angiotensin II. Since valsartan acts at the receptor, it can provide more complete angiotensin II antagonism since angiotensin II is generated by other enzymes as well as ACE. Also, valsartan does not affect the metabolism of bradykinin like ACE inhibitors do.
 

Specification of Analysis

Product Name		Valsartan
Reference		USP
Test Items		Specifications		Results
Characters	Description	White or off-white powder. Odorless.		White powder. Odorless
		*Slightly hygroscopy.		Conform
	*Solubility	Freely soluble in ethanol, sparingly soluble in ethyl a'cetate, slightly soluble in dichloromethan'e, practically insoluble in water		Conform
Identification		1) Infrared absorption spectrophotometry: corresponds to the reference standard.		Conform
		2) The retention time of the major peak in the chromatogram of the assay preparation corresponds to that of the standard preparation, as obtained in the Assay.		Conform
Water (KF)		≤2.0%		0.3%
Absorbance		≤0.02 (λ=420nm, C=0.05g/ml, L=1cm)		<0.01
Residue on ignition		≤0.1%		<0.1%
D-Valsartan (HPLC)		≤1.0%		0.22%
Related substances (HPLC)		Butyryl-Valsartan ≤0.2%		0.01%
		Benzyl-Valsartan ≤0.1%		<LOD(LOD:0.02%)
		Any other individual impurity≤0.10%		0.03%
		Total impurities excluding D-Valsartan≤0.3%		0.06%
Residual solvents (GC)		Ethanol≤5000ppm		<LOD(LOD:2ppm)
		Ethyl a'cetate≤5000ppm		3149ppm
		Toluen'e≤890ppm		19ppm
Assay (HPLC)		98.0-102.0% (calculated on anhydrous,solvent-free basis)		100.7%
Conclusion		Complies with USP