Best Raw Material Apixaban Powder CAS 503612-47-3

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: White Powder
• Purity: >99%
• Model NO.: Frazer-Apixaban
• Appearance: White Powder
• CAS No: 503612-47-3
• Shelf Life: 2 Years
• Test Method: HPLC
• MOQ: 1kg
• Storage: Store Cool Dry Place
• Resource: Natural
• Quality Requirement: Strictly Quality Control
• Market: Worldwide
• Service: Welcome to Visit Us
• Delivery Time: 7-10days
• Mf: C25h25n5o4
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 2500kg/Month

Product Description

Best Raw Material Apixaban Powder CAS 503612-47-3

Certificate of Analysis

Product name	Apixaban
Items	Standards	Results
Appearance	White to off-white solid powder	Complies
Identification	By HNMR	Complies
	By HPLC	Complies
Loss on Drying	≤ 0.50%	0.10%
Heavy Metals	≤ 20ppm	Complies
Residue on Ignition	≤ 0.10%	0.08%
Related Substances	Any single impurity: ≤0.10%	0.05%
	Total impurities: ≤0.50%	0.10%
HPLC	≥ 99.5%	99.90%
Assay(HPLC basis on drying)	98.0%~102.0%	99.88%
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight,light-resistant containers in a cool place

What is Apixaban?

Apixaban is a highly selective, reversible, and direct inhibitor of Human Factor X and Rabbit Factor X with Ki of 0.08 nM and 0.17 nM, respectively. Apixaban exhibits a high degree of potency, selectivity, and efficacy on Factor X with Ki of 0.08 nM and 0.17 nM for Human Factor X and Rabbit Factor X, respectively. In vitro, Apixaban prolongs the clotting times of normal human plasma with theconcentrations (EC2x) of 3.6 μM, 0.37 μM, 7.4 μM, and 0.4 μM, which are required respectively to double the prothrombin time (PT),modified prothrombin time (mPT), activated partial thromboplastin time (APTT) and HepTest. Besides, Apixaban shows the highestpotency in human and rabbit plasma, but less potency in rat and dog plasma in both the PT and APTT assays.

Function and Application 

A key component in helping our customers be first to market is a responsive supply chain. We achieve this by making sure that all our facilities are operating efficiently and to the latest standards of quality, safety, and productivity. A strong interconnect between business and factories allows for a quick reaction to dynamic market changes, so that we can avert shortages and meet sudden surges in demand.