| Powder: | Yes |
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| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Children, Adult |
| State: | White Powder |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Specification of Analysis
| Items | Standards | Results | |
| Appearance | White or off-white solid powder | Complies | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Melting Point | 95ºC~105ºC | 101ºC~102ºC | |
| Loss on Drying | ≤ 1.00% | 0.12% | |
| Heavy Metals | ≤ 20ppm | Complies | |
| Residue on Ignition | ≤ 0.10% | 0.05% | |
| Isomer | ≤ 0.15% | ND | |
| Related Substances | Any single impurity: ≤0.50% | 0.45% | |
| Total Impurities: ≤1.00% | 0.67% | ||
| Purity(HPLC) | ≥ 99.00% | 99.33% | |
| Reference Standard | In-house Standard | ||
| Conclusion | The product complied to In-house standard. | ||
| Storage | Preserve in tight,light-resistant containers in a cool place | ||
Olopatadine hydrochloride is an anti-allergic drug. It has the dual effects of inhibiting the release of histamine and selectively antagonizing HI receptors, and has no central nervous system inhibition and cardiac toxic side effects that are common with HI receptor antagonist antiallergic drugs. The drug can not only inhibit the release of histamine from mast cells, but also antagonize H1 receptors more selectively, and has no effect on α adrenergic receptors, dopamine receptors, and M1 and M2 receptors. Among them, the side effects of the central nervous system are few. , Is a new generation of antiallergic drugs of choice.
Fuction and Application
Olopatadine is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.
Service we can provide:
1. Any inquiries will be replied within 24 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
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