High Quality Antiviral Entecavir Powder CAS 142217-69-4 with Best Price

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• Purity: >99%
• Appearance: White Powder
• Model NO.: Frazer-Entecavir
• Shelf Life: 2 Years
• Storage: Keep in Cool and Dry Place
• Delivery: Express 5-7 Days Arrive
• Test Method: HPLC
• Assay: 99%
• MOQ: 1kg
• Shipping Area: Worldwide/All Countries
• CAS: 209216-23-9
• Service: Good Service
• Delivery Method: FedEx/DHL/Special Line
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Xi′an Frazer Biotech Co., Ltd.
• Origin: China
• Production Capacity: 200kg Per Month

Product Description

High Quality Antiviral Entecavir Powder CAS 142217-69-4 with Best Price

Specification of Analysis

Items	Standards		Results
Appearance	White or off-white solid powder		White solid powder
Identification	By IR		Complies
	By HPLC		Complies
Specific Rotation	+24.0°~+28.0°(DMF:MeOH=1:1 c=1%)		+9.5°
pH	5.5~7.5		6.8
Water Content	5.6%~7.2%		6.1%
Heavy Metal	≤ 20ppm		Complies
Residue on Ignition	≤ 0.10%		0.04%
Enantiomer	≤ 0.20%		ND
Residual Solvents	M'ethanol: ≤3000ppm		ND
	D'ichloromethane: ≤600ppm		ND
	T'etrahydrofuran: ≤720ppm		ND
	T'oluene: ≤890ppm		ND
	H'exane: ≤290ppm		ND
	DMF: ≤880ppm		ND
Related Substances	Any single impurity: ≤0.10%		0.05%
	Total Impurities: ≤0.30%		0.07%
Assay (HPLC basis on drying)	98.0%~102.0%		99.90%
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight,light-resistant containers in a cool place

Description:
Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. In mammalian cells, entecavir is efficiently phosphorylated to the active triphosphate form, which competes with the natural substrate deoxyguanosine triphosphate and functionally inhibits all three activities of the HBV polymerase: (1) base priming, (2) reverse transcription of the negative strand from the pregenomic messenger RNA, and (3) synthesis of the positive strand of HBV DNA.The most common adverse events associated with the use of entecavir are similar to those typically seen with HBV therapy and include headache, abdominal pain, diarrhea, fatigue, and dizziness.

Function:
Entecavir Hydrate is a new kind of cyclopentyl acyl guanosine anti-hepatitis b virus drugs with its pharmacological effects similar as entecavir. It is clinically applied to the treatment of adult chronic hepatitis b in which there is active viral replication, increased serum transaminase ALT or active lesions showed from liver histology. 
Entecavir Monohydrate is a kind of analogues of guanine nucleoside which has inhibitory on the polymerase of hepatitis b virus (HBV). It can become active triphosphate salts through phosphorylation. The triphosphate salt has a half-life of 15 hours inside a cell. Through completion with the natural substrates of HBV polymerase, guanine nucleoside triphosphate, entecavir triphosphate can suppress all the three types of activities of the virus polymerase (reverse transcriptase): 
(1) The initiation of HBV polymerase.
(2) The formation of the negative chain of reverse transcription of the pre-genome.
(3) The synthesis of HBVDNA positive chain.